Been experimenting with combining NMN and NR together for the past 8 months and honestly the synergistic effect on my NAD+ levels has been amazing - I take 1000mg of each with breakfast and my mitochondrial function feel like they've reverted to my 30s, plus my physician confirmed my biomarkers show significant improvement in glucose regulation and the stack seems to be more effective than either nicotinamide mononucleotide or nicotinamide riboside alone since they access distinct cellular uptake mechanisms with NMN using the Slc12a8 transporter while NR goes through the NRK1 NRK2 enzymes so you're essentially hitting different mechanisms of NAD+ restoration which is essential for SIRT1 function, PARP enzyme support, and reversing the natural NAD+ decline with age that kicks in around our 40s - definitely recommend adding resveratrol as a CD38 enzyme inhibitor to minimize NAD+ degradation and maybe some TMG for metabolic balance.

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